St. John's Wort and Reduced Depressive Symptoms

• The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials.

  • 2022-10-11
  • Meta-Analysis · n = 2,270
  • Advances in clinical and experimental medicine : official organ Wroclaw Medical University 32(2)
  • • Xin Zhao
    • Hong Zhang
    • Yanyan Wu
    • Chun Yu

  • PubMed: 36226689
  • DOI: 10.17219/acem/152942

  2 Insights on

  • Reduced Depressive Symptoms

  • High evidence
  • Clinical

  For patients treated with either SSRIs or SJW, a pooled OR of 2.44 with a 95% confidence interval (95% CI) of 1.33-4.45 was obtained.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes