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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Thistle and Reduced Indirect Bilirubin Level

Doses used in studies

mg/day: 420 (median 420, IQR 420–420) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
No adverse events were noted and both silymarin and placebo were well tolerated.
from: A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms,

1 of 1 paper

A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
- 2009-05
- RCT
- Phytomedicine : international journal of phytotherapy and phytopharmacology 16(5)
- - Samer S El-Kamary
  - Michelle D Shardell
  - Mohamed Abdel-Hamid
  - Soheir Ismail
  - Mohamed El-Ateek
  - Mohamed Metwally
  - Nabiel Mikhail
  - Mohamed Hashem
  - Amr Mousa
  - Amr Aboul-Fotouh
  - Mohamed El-Kassas
  - Gamal Esmat
  - G Thomas Strickland
- PubMed: 19303273
- DOI: 10.1016/j.phymed.2009.02.002
7 Insights on
- Reduced Indirect Bilirubin Level
- High evidence
- Clinical
There was a reduction in indirect bilirubin among those assigned to silymarin (p=0.012)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
140 mg three times daily