Calcium and Improved Bone Mineral Density

• Comparative efficacy and safety of anti-osteoporotic therapies for kidney transplant recipients: a systematic review and network meta-analysis.

  • 2025-11-03
  • Systematic Review · n = 66
  • Frontiers in endocrinology 16
  • • Xiaopei Liu
    • Xingyao Li
    • Yanhong Zhao
    • Qi Gao
    • Yuan Xue
    • Zhongheng Wu
    • Xingmin Shi
    • Xili Wu

  • PubMed: 41255525
  • DOI: 10.3389/fendo.2025.1689233

  1 Insight on

  • Improved Bone Mineral Density

  • High evidence
  • Clinical

  calcium showing MD=-5.85 (95%CI=-7.72 to -3.98)

  Effect

  Neutral

  Effect size

  Small

  Significant

  Yes

• Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot Trial.

  • 2025-11-03
  • RCT
  • The Journal of clinical endocrinology and metabolism 111(5)
  • • Trupti N Prasad
    • Rimesh Pal
    • Sanjay K Bhadada
    • Sant Ram
    • Veenu Singla
    • Seema Pulami

  • PubMed: 41183496
  • DOI: 10.1210/clinem/dgaf589

  3 Insights on

  • Improved Bone Mineral Density

  • High evidence
  • Clinical

  Zoledronate improved only tibial total vBMD.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  standard of care (calcium/cholecalciferol) – specific dose not stated