Zinc and Increased Serum Free Thyroxine Levels

• Additional treatment strategies for hypothyroidism: a network meta-analysis.

  • 2026-03-13
  • Systematic Review · n = 508
  • Endocrine connections 15(4)
  • • Xingang Lv
    • Wentao Qin
    • Jiarui Li
    • Likun Du

  • PubMed: 41838451
  • DOI: 10.1530/ec-26-0011

  2 Insights on

  • Increased Serum Free Thyroxine Levels

  • High evidence
  • Clinical

  LT4 + zinc (Zn) + magnesium (Mg) + vitamin A (VA) raised free thyroxine (FT4) (SMD = 1.95, 95% CrI: 1.37, 2.53, CINeMA: high certainty)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes