Bacillus clausii SC-109 and Improved Gastrointestinal Health

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial moderate-sized effects of Bacillus clausii SC-109 on gastrointestinal health. However, the evidence base is limited to reviews without reported sample sizes, statistical significance, or consistent study durations, and one study focused on domestic cats rather than humans.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). None of the included studies reported statistically significant findings — effect may be smaller than the predominant direction suggests. All three studies are narrative reviews, not primary human trials, which limits the strength of the conclusions.

Generated Jun 11, 2026

3 of 3 papers

A Review of Probiotic Supplementation and Its Impact on the Health and Well-Being of Domestic Cats.
- 2025-07-28
- Review
- Veterinary sciences 12(8)
- - Bhagavathi Sundaram Sivamaruthi
  - Periyanaina Kesika
  - Chaiyavat Chaiyasut
  - Pranom Fukngoen
  - Natarajan Sisubalan
- PubMed: 40872654
- DOI: 10.3390/vetsci12080703
2 Insights on
- Improved Gastrointestinal Health
- Low evidence
Probiotic strains such as Lactobacillus, Bifidobacterium, Bacillus, Enterococcus, and Saccharomyces have demonstrated beneficial effects, including the modulation of the gut microbiota, a reduction in inflammation, and an improvement in gastrointestinal symptoms.
Effect
Beneficial
Effect size
Moderate
The Potential of Bacillus Species as Probiotics in the Food Industry: A Review.
- 2024-08-02
- Review
- Foods (Basel, Switzerland) 13(15)
- - Jessie Payne
  - Danielle Bellmer
  - Ravi Jadeja
  - Peter Muriana
- PubMed: 39123635
- DOI: 10.3390/foods13152444
5 Insights on
- Improved Gastrointestinal Health
- Low evidence
consuming Bacillus clausii SC-109 resulted in improved intestinal microflora balance and reduced gastrointestinal discomfort
Effect
Beneficial
Effect size
Moderate
Antimicrobial Bacillus: Metabolites and Their Mode of Action.
- 2022-01-12
- Review
- Antibiotics (Basel, Switzerland) 11(1)
- - Charlie Tran
  - Ian E Cock
  - Xiaojing Chen
  - Yunjiang Feng
- PubMed: 35052965
- DOI: 10.3390/antibiotics11010088
1 Insight on
- Improved Gastrointestinal Health
- Low evidence
Consuming Bacillus clausii SC-109 was associated with improved health outcomes in the study, including beneficial effects on gut-related indicators and overall host health.
Effect
Beneficial
Effect size
Moderate

Bacillus clausii SC-109 and Improved Gastrointestinal Health

A Review of Probiotic Supplementation and Its Impact on the Health and Well-Being of Domestic Cats.

The Potential of Bacillus Species as Probiotics in the Food Industry: A Review.

Antimicrobial Bacillus: Metabolites and Their Mode of Action.