Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research

Bacillus subtilis DE111 and Improved Vascular Endothelial Function

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Of the 3 studies, 2 reported neutral effects with small effect sizes (trending improvements, not significant), and 1 reported beneficial moderate effects in a mouse model. The overall evidence is predominantly neutral with small effects, and no consistent dose or form data are available.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Two of the studies appear to be duplicate records of the same human trial. The only statistically significant benefit was observed in an animal model, which may not translate to humans. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jun 11, 2026
3 of 3 papers
Back to top