Across 3 studies, 1 animal study reported a moderate beneficial effect on endothelial function, while 2 human RCTs (from the same trial) found neutral effects with small, non-significant trends (P=0.05). The only statistically significant outcome is from a mouse model, and human data remain inconclusive. No consistent dose, form, or study duration information was reported across studies.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The only statistically significant benefit is from a mouse model, not from human trials. The two human entries represent the same single RCT, further limiting the evidence.
trending improvements in endothelial function (P=0.05, CI: -0.003, 0.370)
PB consumption significantly attenuated WD diet-induced endothelial dysfunction
In addition we observed trending improvements in endothelial function (P=0.05, CI: -0.003, 0.370)