Bacillus subtilis HU58 and Reduced Abdominal Pain

• Effects of spore-forming probiotic Bacillus subtilis HU58™ in children with antibiotic-associated diarrhoea: a randomised, double-blind, placebo-controlled trial.

  • 2025-07-25
  • RCT · n = 68
  • Beneficial microbes 17(1)
  • • K Sorensen
    • P Jog
    • S Mankar
    • C Holz
    • S Jadhav

  • PubMed: 40716758
  • DOI: 10.1163/18762891-bja00086

  3 Insights on

  • Reduced Abdominal Pain

  • High evidence
  • Rigorous Journal

  Significantly greater decreases in abdominal pain VAS scores were observed among those receiving the probiotic versus placebo at day 3 (-7.4 [SE 0.5] versus -1.9 [SE 0.3], P < 0.001) and day 7 (-9.1 [SE 0.3] versus -8.5 [SE 0.2], P < 0.001).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes