Bacillus subtilis MTCC 5856 and Reduced Depression Symptoms

• Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study

  • 2018-07-04
  • RCT · n = 40
  • Food & Nutrition Research 62(0)
  • • M. Majeed
    • K. Nagabhushanam
    • S. Arumugam
    • Shaheen Majeed
    • Furqan Ali

  • PubMed: 29997457
  • DOI: 10.29219/fnr.v62.1218

  7 Insights on

  • Reduced Depression Symptoms

  • High evidence
  • Highly Cited
  • Rigorous Journal

  Significant change (p = 0.01) in favour of the B. coagulans MTCC 5856 was observed for the primary efficacy measure Hamilton Rating Scale for Depression (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), Center for Epidemiological Studies Depression Scale (CES-D)...All the safety parameters remained well within the normal clinical range and had no clinically significant difference between the screening and at the end of the study.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes