Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of "Psychobiotics".
- 2025-02-25
- Systematic Review
- International journal of molecular sciences 26(5)
- Stefania Garzone
- Ioannis Alexandros Charitos
- Manuela Mandorino
- Maria Elena Maggiore
- Loredana Capozzi
- Bujar Cakani
- Gabriel César Dias Lopes
- Luisella Bocchio-Chiavetto
- Marica Colella
- PubMed: 40076598
- DOI: 10.3390/ijms26051972
- High evidence
- Rigorous Journal
Psychobiotics can significantly reduce symptoms of various psychiatric disorders by influencing neurotransmitter levels, regulating the hypothalamic-pituitary-adrenal (HPA) axis, and improving gut barrier function through short-chain fatty acids (SCFAs) and other metabolites.
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes