Bifidobacterium animalis subsp. lactis Bi-07 and Reduced Anxiety-like Behavior

• A Synbiotic of Bifidobacterium animalis subsp. lactis BB-12 and 2'-FL Alleviate Infant Diarrhea and Anxiety-like Behaviors via Gut Microbiota Modulation in an EPEC O127 Infection Model.

  • 2025-09-29
  • Nutrients 17(19)
  • • Zhuo Liu
    • Wenxiu Wang
    • Ning Li
    • Jinkuan Chen
    • Qianxu Wang
    • Mengzhen Jia
    • Xiaorui Wang
    • Bo Zhang
    • Nan Sheng
    • Zhigang Liu

  • PubMed: 41097176
  • DOI: 10.3390/nu17193099

  11 Insights on

  • Reduced Anxiety-like Behavior

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Administration of the synbiotic not only markedly improved diarrhea, anxiety-like behavior, colon inflammation, and gut barrier function

  Effect

  Beneficial

  Effect size

  Moderate

• Bifidobacterium animalis subsp. lactis genome resources and metabolite profiling at the strain level and their ability to alleviate anxiety-like behavior in a sleep-deprived mouse model.

  • 2025-12
  • Engineering microbiology 5(4)
  • • Yao-Kun Zhang
    • Liang Zhang
    • Xue Ni
    • Shu-Wen Zhang
    • Min-Zhi Jiang
    • Si-Lu Zhang
    • Guo-Xun Xiao
    • He Jiang
    • Ming-Xia Bi
    • Yu-Lin Wang
    • Chang Liu
    • Shuang-Jiang Liu

  • PubMed: 41982656
  • DOI: 10.1016/j.engmic.2025.100228

  4 Insights on

  • Reduced Anxiety-like Behavior

  • Low evidence

  WLBA3 reduced inflammation and oxidative stress by inhibiting the NLRP3 inflammasome pathway and modulating gut microbiota... which in turn significantly improved weight gain and fatigue resistance, attenuated cognitive function, and anxiety-like behavior.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes