Bifidobacterium animalis subsp. lactis HN019 and Improved Bowel Movement Frequency

• Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial

  • 2018-02-08
  • RCT · n = 228
  • Gut Microbes 9(3)
  • • A. Ibarra
    • Mathilde Latreille-Barbier
    • Y. Donazzolo
    • X. Pelletier
    • A. Ouwehand

  • PubMed: 29227175
  • DOI: 10.1080/19490976.2017.1412908

  22 Insights on

  • Improved Bowel Movement Frequency

  • High evidence
  • Rigorous Journal
  • Clinical

  A post hoc analysis of 65 participants with fewer than 3 bowel movements per week (BMF ≤ 3/week) showed a physiologically relevant increase in weekly BMF in the high- (+2.0) and low-dose (+1.7) HN019 groups-by RMANOVA, the HN019 groups with BMF ≤ 3/week, pooled together, had a higher BMF versus placebo (P value = 0.01).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  1 × 10^9 CFU/day or 1 × 10^10 CFU/day (pooled analysis in subgroup with BMF ≤ 3/week)

• Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

  • 2021-12-14
  • Review
  • Frontiers in Nutrition 8
  • • Jing Cheng
    • A. Laitila
    • A. Ouwehand

  • PubMed: 34970580
  • DOI: 10.3389/fnut.2021.790561

  9 Insights on

  • Improved Bowel Movement Frequency

  • Low evidence

  Furthermore, B. lactis HN019™ reduced intestinal transit time and increased bowel movement frequency in functional constipation, potentially by modulating gut-brain-microbiota axis, mainly via serotonin signaling pathway, through short chain fatty acids derived from microbial fermentation.

  Effect

  Beneficial

  Effect size

  Large