Bifidobacterium bifidum Bb-02 and Improved Intestinal Barrier Function

• Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene.

  • 2026-01-21
  • NPJ biofilms and microbiomes 12(1)
  • • Raz Abdulqadir
    • Rana Al-Sadi
    • Yash Gupta
    • Manmeet Rawat
    • Thomas Ma

  • PubMed: 41559082
  • DOI: 10.1038/s41522-025-00903-7

  1 Insight on

  • Improved Intestinal Barrier Function

  • Low evidence

  we show that BB1 upregulation of intestinal TJ barrier correlated with an increase in occludin gene activity ... and protein expression, with no changes in other TJ proteins

  Effect

  Beneficial

  Effect size

  Moderate

• Bifidobacterium bifidum postbiotics prevent Salmonella Pullorum infection in chickens by modulating pyroptosis and enhancing gut health.

  • 2025-04
  • Clinical Trial
  • Poultry science 104(4)
  • • Yuhao Chen
    • Fuqiang Zhu
    • Guobi Yu
    • Nana Peng
    • Xinying Li
    • Meng Ge
    • Lei Yang
    • Wei Dong

  • PubMed: 40043668
  • DOI: 10.1016/j.psj.2025.104968

  2 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  BbP restored intestinal barrier function by upregulating the expression of tight junction proteins, including zonula occludens-1 (ZO-1), Occludin, and Claudin-1.

  Effect

  Beneficial

  Effect size

  Moderate