Bifidobacterium bifidum G9-1 and Increased Defecation Frequency

• Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study).

  • 2026-01-08
  • Clinical Trial · n = 30
  • Journal of diabetes investigation 17(3)
  • • Fuki Ikeda
    • Junko Sato
    • Hidenori Yoshii
    • Masahiro Sugawara
    • Hiroaki Satoh
    • Yukiko Sugawara
    • Hirotsugu Uzawa
    • Daisuke Sugimoto
    • Reina Muto
    • Yuya Nishida
    • Hirotaka Watada

  • PubMed: 41504339
  • DOI: 10.1111/jdi.70236

  6 Insights on

  • Increased Defecation Frequency

  • High evidence

  Defecation frequency significantly increased by 0.2 ± 0.4 from baseline to week 6 (P = 0.026).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes