Bifidobacterium breve MAK40B22B and Improved Cognitive Function

• Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial

  • 2022-06-28
  • RCT · n = 130
  • Journal of Alzheimer's Disease 88(1)
  • • D. Asaoka
    • Jinzhong Xiao
    • T. Takeda
    • N. Yanagisawa
    • Takahiro Yamazaki
    • Yoichiro Matsubara
    • Hideki Sugiyama
    • Noemi Endo
    • Motoyuki Higa
    • K. Kasanuki
    • Y. Ichimiya
    • S. Koido
    • Kazuya Ohno
    • François Bernier
    • N. Katsumata
    • A. Nagahara
    • H. Arai
    • T. Ohkusa
    • Nobuhiro Sato

  • PubMed: 35570493
  • DOI: 10.3233/jad-220148

  4 Insights on

  • Improved Cognitive Function

  • High evidence
  • Rigorous Journal

  Improvement of cognitive function was observed on some subscales scores only likely due to the lower sensitiveness of these tests for MCI subjects.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

  • 2020-09-01
  • RCT · n = 80
  • Journal of Alzheimer's Disease 77(1)
  • • Jinzhong Xiao
    • N. Katsumata
    • F. Bernier
    • Kazuya Ohno
    • Yuki Yamauchi
    • T. Odamaki
    • K. Yoshikawa
    • Kumie Ito
    • Toshiyuki Kaneko

  • PubMed: 32623402
  • DOI: 10.3233/JAD-200488

  7 Insights on

  • Improved Cognitive Function

  • High evidence
  • Highly Cited
  • Rigorous Journal

  RBANS total score was significantly improved in probiotic group compared with placebo... after 16 weeks of consumption, in particular with significant improvement in domain scores of immediate memory, visuospatial/constructional, and delayed memory (p < 0.0001)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised, double-blind, placebo-controlled trial.

  • 2019-05-28
  • RCT · n = 121
  • Beneficial Microbes 10(5)
  • • Y. Kobayashi
    • T. Kuhara
    • M. Oki
    • J.‐Z. Xiao

  • PubMed: 31090457
  • DOI: 10.3920/BM2018.0170

  9 Insights on

  • Improved Cognitive Function

  • High evidence
  • Highly Cited

  the subscale 'immediate memory' of RBANS and MMSE total score in the subjects with low RBANS total score at baseline.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

  • 2021-05-11
  • Clinical Trial
  • Nutrients 13(5)
  • • G. Zhu
    • Jianxin Zhao
    • Hao Zhang
    • Wei Chen
    • Gang Wang

  • PubMed: 34064762
  • DOI: 10.3390/nu13051602

  11 Insights on

  • Improved Cognitive Function

  • Low evidence
  • Animal Study

  Overall, these findings reveal that *B. breve* CCFM1025 and WX have beneficial effects on cognition via the modulation of the gut microbiome, and thus represent a novel probiotic dietary intervention for delaying the progression of AD.

  Effect

  Beneficial

  Effect size

  Large