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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Bifidobacterium breve MAK40B22B and Improved Cognitive Function

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 randomized controlled trials, all reported statistically significant beneficial effects of Bifidobacterium breve MAK40B22B on cognitive function in older adults with suspected mild cognitive impairment or memory complaints. Effect sizes were mixed (small to large), with the largest benefit observed on immediate and delayed memory subscales. Evidence is limited to a single clinical population and small number of studies.

  • Studied populations: older adults with mild cognitive impairment or subjective memory complaints

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Dosing information was not extractable from the studies, so no dose range can be recommended. All studies were conducted in a narrow clinical population (older adults with suspected MCI), so benefits may not generalize to healthy older adults or other age groups.

Generated Jun 11, 2026
4 of 4 papers
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