Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial
- 2020-09-01
- Journal of Alzheimer's Disease 77(1)
- Jinzhong Xiao
- N. Katsumata
- F. Bernier
- Kazuya Ohno
- Yuki Yamauchi
- T. Odamaki
- K. Yoshikawa
- Kumie Ito
- Toshiyuki Kaneko
- PubMed: 32623402
- DOI: 10.3233/JAD-200488
Abstract
Background: Probiotics use has been associated with modulation of inflammation and considered as a possible intervention for CNS diseases such as mild cognitive impairment (MCI) and dementia.
Objective: We aimed to test the effect of the probiotic strain, Bifidobacterium breve A1 (MCC1274), to restore cognition in a physically healthy, suspected MCI population.
Methods: In this randomized, double-blind, placebo-controlled trial, 80 healthy older adults suffering from MCI were divided into two even groups to receive once daily either probiotic (B. breve A1, 2×1010 CFU) or placebo for 16 weeks using a computer-generated algorithm. Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Japanese version of the MCI Screen (JMCIS) tests before and after the study as primary and secondary endpoints, respectively.
Results: 79 participants completed the study, and no adverse events were observed. RBANS total score was significantly improved in probiotic group compared with placebo (mean between-group difference 11.3 [95% CI 6.7 to 15.8]; p < 0.0001) after 16 weeks of consumption, in particular with significant improvement in domain scores of immediate memory, visuospatial/constructional, and delayed memory (p < 0.0001), in both intention-to-treat (ITT) analysis and per-protocol (PP) analysis. JMCIS score was also improved versus placebo in ITT analysis (p = 0.052) and PP analysis (p = 0.036).
Conclusion: Study results indicate B. breve A1 is a safe and effective approach for improving memory functions of suspected MCI subjects.
Keywords: Bifidobacterium; clinical trial; dementia; memory; mild cognitive impairment; probiotics.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Bifidobacterium breve | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve | Improved Cognitive Screen Score | Beneficial | Moderate |
Bifidobacterium breve | Improved Delayed Memory | Beneficial | Large |
Bifidobacterium breve | Improved Immediate Memory | Beneficial | Large |
Bifidobacterium breve | Improved Visuospatial Constructional Skills | Beneficial | Large |
Bifidobacterium breve Bb-03 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve Bb-03 | Improved JMCIS Score | Beneficial | Moderate |
Bifidobacterium breve Bbr8 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve Bbr8 | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve BR-03 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve BR-03 | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve BR03 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve HA-129 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve HA-129 | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve IDCC 4401 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve IDCC 4401 | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve M-16V | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve M-16V | Improved JMCIS Score | Beneficial | Moderate |
Bifidobacterium breve MAK40B22B | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve MAK40B22B | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve R0070 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve R0070 | Improved Delayed Memory | Beneficial | Large |
Bifidobacterium breve R0070 | Improved Immediate Memory | Beneficial | Large |
Bifidobacterium breve R0070 | Improved JMCIS Score | Beneficial | Moderate |
Bifidobacterium breve R0070 | Improved Visuospatial Constructional Skills | Beneficial | Large |
Bifidobacterium breve Rosell-70 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve Rosell-70 | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve SD5206 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve SD5206 | Improved JMCIS Score | Beneficial | Moderate |
Bifidobacterium breve UABbr-11 | Improved Cognitive Function | Beneficial | Large |
Bifidobacterium breve UABbr-11 | Improved Memory Function | Beneficial | Large |
Bifidobacterium breve VPro 52 | Improved Cognitive Function | Beneficial | Large |