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Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

  • 2020-09-01
  • Journal of Alzheimer's Disease 77(1)
    • Jinzhong Xiao
    • N. Katsumata
    • F. Bernier
    • Kazuya Ohno
    • Yuki Yamauchi
    • T. Odamaki
    • K. Yoshikawa
    • Kumie Ito
    • Toshiyuki Kaneko

Abstract

Background: Probiotics use has been associated with modulation of inflammation and considered as a possible intervention for CNS diseases such as mild cognitive impairment (MCI) and dementia.

Objective: We aimed to test the effect of the probiotic strain, Bifidobacterium breve A1 (MCC1274), to restore cognition in a physically healthy, suspected MCI population.

Methods: In this randomized, double-blind, placebo-controlled trial, 80 healthy older adults suffering from MCI were divided into two even groups to receive once daily either probiotic (B. breve A1, 2×1010 CFU) or placebo for 16 weeks using a computer-generated algorithm. Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Japanese version of the MCI Screen (JMCIS) tests before and after the study as primary and secondary endpoints, respectively.

Results: 79 participants completed the study, and no adverse events were observed. RBANS total score was significantly improved in probiotic group compared with placebo (mean between-group difference 11.3 [95% CI 6.7 to 15.8]; p < 0.0001) after 16 weeks of consumption, in particular with significant improvement in domain scores of immediate memory, visuospatial/constructional, and delayed memory (p < 0.0001), in both intention-to-treat (ITT) analysis and per-protocol (PP) analysis. JMCIS score was also improved versus placebo in ITT analysis (p = 0.052) and PP analysis (p = 0.036).

Conclusion: Study results indicate B. breve A1 is a safe and effective approach for improving memory functions of suspected MCI subjects.

Keywords: Bifidobacterium; clinical trial; dementia; memory; mild cognitive impairment; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breveImproved Cognitive FunctionBeneficial
Large
Bifidobacterium breveImproved Cognitive Screen ScoreBeneficial
Moderate
Bifidobacterium breveImproved Delayed MemoryBeneficial
Large
Bifidobacterium breveImproved Immediate MemoryBeneficial
Large
Bifidobacterium breveImproved Visuospatial Constructional SkillsBeneficial
Large
Bifidobacterium breve Bb-03Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve Bb-03Improved JMCIS ScoreBeneficial
Moderate
Bifidobacterium breve Bbr8Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve Bbr8Improved Memory FunctionBeneficial
Large
Bifidobacterium breve BR-03Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve BR-03Improved Memory FunctionBeneficial
Large
Bifidobacterium breve BR03Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve HA-129Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve HA-129Improved Memory FunctionBeneficial
Large
Bifidobacterium breve IDCC 4401Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve IDCC 4401Improved Memory FunctionBeneficial
Large
Bifidobacterium breve M-16VImproved Cognitive FunctionBeneficial
Large
Bifidobacterium breve M-16VImproved JMCIS ScoreBeneficial
Moderate
Bifidobacterium breve MAK40B22BImproved Cognitive FunctionBeneficial
Large
Bifidobacterium breve MAK40B22BImproved Memory FunctionBeneficial
Large
Bifidobacterium breve R0070Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve R0070Improved Delayed MemoryBeneficial
Large
Bifidobacterium breve R0070Improved Immediate MemoryBeneficial
Large
Bifidobacterium breve R0070Improved JMCIS ScoreBeneficial
Moderate
Bifidobacterium breve R0070Improved Visuospatial Constructional SkillsBeneficial
Large
Bifidobacterium breve Rosell-70Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve Rosell-70Improved Memory FunctionBeneficial
Large
Bifidobacterium breve SD5206Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve SD5206Improved JMCIS ScoreBeneficial
Moderate
Bifidobacterium breve UABbr-11Improved Cognitive FunctionBeneficial
Large
Bifidobacterium breve UABbr-11Improved Memory FunctionBeneficial
Large
Bifidobacterium breve VPro 52Improved Cognitive FunctionBeneficial
Large
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