Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial
- 2018-05-02
- RCT · n = 341
- Pediatric Research 83(6)
- J. Escribano
- N. Ferré
- M. Gispert-Llauradó
- V. Luque
- C. Rubio-Torrents
- M. Zaragoza-Jordana
- I. Polanco
- F. Codoñer
- E. Chenoll
- M. Morera
- J. A. Moreno-Muñoz
- M. Rivero
- R. Closa-Monasterolo
- PubMed: 29538368
- DOI: 10.1038/pr.2018.34
- High evidence
- Large Human Trial
- Rigorous Journal
Constipation incidence was higher (odds ratio (OR) 2.67 (1.09-6.50)) and stool frequency lower (2.0±1.0 vs. 2.6±1.3 stools/day, P=0.038) in the Control group after 4 weeks.
- Effect
- Harmful
- Effect size
- Moderate
- Significant
- Yes