Bifidobacterium infantis M-63 and Reduced Pro-inflammatory Cytokine Levels

Doses used in studies

CFU/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study

Time to effect

Median: 11.9 weeks · IQR 11.9 weeks–11.9 weeks · Range 11.9 weeks–11.9 weeks — Reported in 1 of 1 study

1 of 1 paper

Anti-inflammatory effects of Bifidobacterium infantis M-63 during the early postnatal period in term infants.

2025-07-18
RCT
Pediatric research 99(5)
- Chendong Xu
- Toshitaka Odamaki
- Akari Hiraku
- Setsuko Nakata
- Satoshi Arai
- Noriyuki Iwabuchi
- Miyuki Tanaka
- Takahisa Tsuno
- Masahiko Nakamura

PubMed: 40681696
DOI: 10.1038/s41390-025-04263-y

5 Insights on

Reduced Pro-inflammatory Cytokine Levels

High evidence
Infants

Administering Bifidobacterium infantis M-63 significantly increased gut Bifidobacterium, whereas Enterobacteriaceae abundance and proinflammatory cytokine levels decreased.

Effect: Beneficial
Effect size: Small
Significant: Yes
Dose: 1.0 × 10^9 CFU/day