Bifidobacterium infantis MAK22B04I and Reduced Pro-Inflammatory Cytokines

• Bifidobacterium infantis attenuates colitis by regulating T cell subset responses.

  • 2015-09-14
  • Clinical Trial
  • World Journal of Gastroenterology 20(48)
  • • L. Zuo
    • Kai-Tao Yuan
    • Li Yu
    • Qing-Hong Meng
    • P. C. Chung
    • Ding-hua Yang

  • PubMed: 25561798
  • DOI: 10.3748/wjg.v20.i48.18316

  4 Insights on

  • Reduced Pro-Inflammatory Cytokines

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Feeding high dose B. infantis for 3 wk before colitis induction decreased the inflammatory cell infiltration and goblet cell depletion and restored the intestinal epithelium.

  Effect

  Beneficial

  Effect size

  Large

• The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.

  • 2008-12
  • Clinical Trial
  • Journal of Psychiatric Research 43(2)
  • • L. Desbonnet
    • L. Garrett
    • G. Clarke
    • J. Bienenstock
    • T. Dinan

  • PubMed: 18456279
  • DOI: 10.1016/j.jpsychires.2008.03.009

  8 Insights on

  • Reduced Pro-Inflammatory Cytokines

  • Low evidence
  • Highly Cited
  • Animal Study

  However, there was a significant attenuation of IFN-gamma, TNF-alpha and IL-6 cytokines following mitogen stimulation (p<0.05) in probiotic-treated rats relative to controls.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes