Bifidobacterium lactis Bb-02 and Improved Glycemic Control

• Glucose Parameters, Inflammation Markers, and Gut Microbiota Changes of Gut Microbiome-Targeted Therapies in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  • 2025-06-09
  • Meta-Analysis · n = 3,390
  • The Journal of clinical endocrinology and metabolism 110(10)
  • • Xin Zhou
    • Wenbin Zheng
    • Wen Kong
    • Jiaoyue Zhang
    • Yunfei Liao
    • Jie Min
    • Tianshu Zeng

  • PubMed: 40489582
  • DOI: 10.1210/clinem/dgaf340

  5 Insights on

  • Improved Glycemic Control

  • High evidence

  MTTs intervention decreased fasting plasma glucose (MD = -7.97 mg/dL [95% CI = -10.82, -5.12]; P < .00001), 2-hour postprandial blood glucose (MD = -43.30 mg/dL [95% CI = -75.83, -10.77]; P = .009), fasting insulin (MD = -1.73 uU/mL [95% CI = -2.63, -0.84]; P = .0001), HbA1c (MD = -0.28%, [95% CI = -0.39, -0.17]; P < .00001), and homeostatic model assessment of insulin resistance (MD = -0.53 [95% CI = -0.85, -0.20]; P = .0002).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes