Bifidobacterium lactis HN019 and Improved Bowel Movement Frequency

• Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial.

  • 2024-10-02
  • RCT · n = 283
  • JAMA network open 7(10)
  • • Jing Cheng
    • Carl Gao
    • Reeta Ala-Jaakkola
    • Sofia D Forssten
    • Markku Saarinen
    • Ashley Hibberd
    • Arthur C Ouwehand
    • Alvin Ibarra
    • Dingqiang Li
    • Anders Nordlund
    • Yingxin Wang
    • Xizhong Shen
    • Haixia Peng
    • Xinjian Wan
    • Xiangjun Meng

  • PubMed: 39356506
  • DOI: 10.1001/jamanetworkopen.2024.36888

  4 Insights on

  • Improved Bowel Movement Frequency

  • High evidence
  • Large Human Trial

  There was no difference in the change of weekly CSBMs from baseline to the end of study between the HN019 (least-square mean change, 0.80 [95% CI, 0.54-1.05]) and placebo (least-square mean change, 0.66 [95% CI, 0.41-0.90]) groups.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  7.0×10^9 CFU/day at start and 4.69×10^9 CFU/day at end of study

• Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial.

  • 2025-05-05
  • RCT
  • Molecular nutrition & food research 69(17)
  • • Reeta Ala-Jaakkola
    • Sofia D Forssten
    • Jing Cheng
    • Flavie Griffon
    • Isabelle Metreau
    • Yves Sturm
    • Jean-Michel Lecerf
    • Yves Donazzolo
    • Jouni Junnila
    • Anders Nordlund
    • Ashley Hibberd
    • Arthur C Ouwehand
    • Alvin Ibarra

  • PubMed: 40320938
  • DOI: 10.1002/mnfr.70081

  16 Insights on

  • Improved Bowel Movement Frequency

  • High evidence

  HN019 was not found to be superior in managing FC compared to placebo.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  daily supplementation