Bifidobacterium longum BB536 and Improved Bowel Movement Frequency

• Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding.

  • 2013-12-10
  • RCT · n = 206
  • World Journal of Gastroenterology 19(14)
  • • Junko Kondo
    • J. Xiao
    • A. Shirahata
    • Mieko Baba
    • Akie Abe
    • Koichi Ogawa
    • T. Shimoda

  • PubMed: 23599642
  • DOI: 10.3748/wjg.v19.i14.2162

  13 Insights on

  • Improved Bowel Movement Frequency

  • High evidence
  • Rigorous Journal

  The combination of Trials 1 and 2 data revealed a modulatory effect of BB536 ingestion on the changes in bowel movements. Significantly increased bowel movements were observed in patients in the low frequency subgroup with significant intergroup differences (P < 0.01). Significantly decreased bowel movements were observed in patients in the high subgroup, but no significant intergroup differences were observed compared with the placebo group.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  approximately 2.5 × 10¹⁰ cfu (BB536-L) and 5 × 10¹⁰ cfu (BB536-H)

• Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by Bifidobacterium longum BB536 supplementation: A RCT.

  • 2024-09-07
  • RCT · n = 24
  • Computational and structural biotechnology journal 20
  • • Yuya Nakamura
    • Shinya Suzuki
    • Shinnosuke Murakami
    • Yuichiro Nishimoto
    • Koichi Higashi
    • Naoki Watarai
    • Junpei Umetsu
    • Chiharu Ishii
    • Yutaro Ito
    • Yuka Mori
    • Mamiko Kohno
    • Takuji Yamada
    • Shinji Fukuda

  • PubMed: 36382178
  • DOI: 10.1016/j.csbj.2022.10.026

  1 Insight on

  • Improved Bowel Movement Frequency

  • High evidence

  B. longum BB536 supplementation can be used to regulate bowel movements ... The responders were predicted by machine learning based on the microbiome and metabolome features of the fecal samples collected before B. longum intake. The abundances of eight bacterial genera were significantly different between responders and nonresponders.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes