Bifidobacterium longum R0175 and Increased Flavanone Metabolite Excretion

• Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.

  • 2015-07
  • Clinical Trial
  • Free radical biology & medicine 84
  • • Gema Pereira-Caro
    • Christine M Oliver
    • Rangika Weerakkody
    • Tanoj Singh
    • Michael Conlon
    • Gina Borges
    • Luz Sanguansri
    • Trevor Lockett
    • Susan A Roberts
    • Alan Crozier
    • Mary Ann Augustin

  • PubMed: 25801290
  • DOI: 10.1016/j.freeradbiomed.2015.03.010

  8 Insights on

  • Increased Flavanone Metabolite Excretion

  • Moderate evidence

  Acute OJ consumption after chronic probiotic intake over 4 weeks resulted in the excretion of 27% of flavanone intake, and excretion of selected phenolic acids also increased significantly to 43% of (poly)phenol intake, corresponding to an overall bioavailability of 70%.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  microencapsulated probiotic, daily supplementation over 4 weeks