Bifidobacterium longum and Impaired Intestinal Barrier Function

• "Bifidobacterium longum-reactive T helper cells as marker for intestinal barrier impairment in ICU patients with sepsis".

  • 2025-12-24
  • Observational · n = 19
  • Gut pathogens 18(1)
  • • Lea-Maxie Haag
    • Markus Müller
    • Jörn Ziegler
    • Malte Lehmann
    • Julia Hecker
    • Rainer Glauben
    • Markus M Heimesaat
    • Friederike Compton
    • Britta Siegmund

  • PubMed: 41444646
  • DOI: 10.1186/s13099-025-00770-9

  1 Insight on

  • Impaired Intestinal Barrier Function

  • Low evidence

  we identified a sepsis-specific T-helper cell signature in peripheral blood ... characterized by an expansion of gut trophic Bifidobacterium longum-reactive T-helper cells, indicating significant intestinal barrier dysfunction during sepsis.

  Effect

  Neutral

  Effect size

  Small