Bifidobacterium longum and Improved Gut Microbiota Composition

• Bifidobacterium longum subsp. infantis B8762 modulates the infant gut-lung axis via microbial and metabolic reprogramming.

  • 2026-06
  • RCT · n = 115
  • Microbial pathogenesis 215
  • • Rui Ma
    • Bo Jia
    • Xiangyang Zhang
    • Zhixin Zhao
    • Feiyan Zhao
    • Min-Tze Liong
    • Adli Ali
    • Intan Juliana Abd Hamid
    • Taufiq Hidayat Hasan
    • Fahisham Taib
    • Zhihong Sun

  • PubMed: 41802657
  • DOI: 10.1016/j.micpath.2026.108431

  3 Insights on

  • Improved Gut Microbiota Composition

  • High evidence

  B8762 significantly altered the gut microbial structure (β-diversity, P < 0.05) without affecting α-diversity. The intervention enriched beneficial taxa including Bifidobacterium longum, Eubacterium limosum, and Roseburia hominis, while reducing potential pathogens such as Staphylococcus aureus and Candida parapsilosis (P < 0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Glucose-Lowering Effects and Safety of Bifidobacterium longum CKD1 in Diabetic Dogs and Cats.

  • 2025-12-18
  • Clinical Trial
  • Microorganisms 13(12)
  • • Yukyung Choi
    • Ji-Eun Kim
    • Kyung Hwan Kim
    • Sunghee Lee
    • Chang Hun Shin

  • PubMed: 41472082
  • DOI: 10.3390/microorganisms13122881

  4 Insights on

  • Improved Gut Microbiota Composition

  • Moderate evidence

  Microbiota analysis revealed an increase in beneficial commensals and short-chain fatty acid producers, along with a reduction in pathobionts.

  Effect

  Beneficial

  Effect size

  Moderate

• Lacto-N-neotetraose and Bifidobacterium longum ssp. infantis together shape the unique gut microbiota and metabolites of allergic mice.

  • 2026-04
  • Journal of dairy science 109(4)
  • • Yi Shan
    • Xue Han
    • Yu Sun
    • Jiuyuan Wang
    • Yanfeng Qu

  • PubMed: 41780875
  • DOI: 10.3168/jds.2025-27877

  3 Insights on

  • Improved Gut Microbiota Composition

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Gut microbiota analysis revealed that LNnT + B. infantis reduced the abundance of the allergy-associated bacterium Desulfovibrio and significantly increased the levels of beneficial bacteria, including Lactobacillus, Limosilactobacillus, and Blautia.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes