Bifidobacterium plantarum and Improved Antioxidant Defense

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

All 3 studies found beneficial moderate-sized effects on improved antioxidant defense. However, all three are review articles with no statistically significant findings, and dosing information was not reported. The evidence is based on general mechanistic reviews and one animal study.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All studies are review articles without primary human trials; no statistically significant findings were reported. The available evidence is overwhelmingly positive, but clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jun 11, 2026

3 of 3 papers

Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.
- 2026-01-21
- Review
- International journal of molecular sciences 27(2)
- - Olga Adriana Caliman-Sturdza
  - Josiana A Vaz
  - Ancuta Veronica Lupaescu
  - Andrei Lobiuc
  - Codruta Bran
  - Roxana Elena Gheorghita
- PubMed: 41596722
- DOI: 10.3390/ijms27021079
8 Insights on
- Improved Antioxidant Defense
- Moderate evidence
- Rigorous Journal
They stimulate anti-inflammatory cytokines (including interleukin 10 (IL-10) and inhibit pro-inflammatory mediators such as tumor necrosis factor-α (TNF-α), partly through the regulation of T cells. Probiotics also produce antioxidant metabolites (e.g., exopolysaccharides and short-chain fatty acids), which enhance the host's resistance to oxidative stress.
Effect
Beneficial
Effect size
Moderate
Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders.
- 2026-02-21
- Review
- Amino acids 58(1)
- - Tushar Adhikari
  - Prerona Saha
- PubMed: 41721117
- DOI: 10.1007/s00726-026-03505-5
6 Insights on
- Improved Antioxidant Defense
- Low evidence
restore polyamine balance, enhance antioxidant defenses, and reduce neuroinflammatory responses
Effect
Beneficial
Effect size
Moderate
Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.
- 2025-12-12
- Review
- Veterinary sciences 12(12)
- - Sahdeo Prasad
  - Bhaumik Patel
  - Prafulla Kumar
  - Rajiv Lall
- PubMed: 41472171
- DOI: 10.3390/vetsci12121191
13 Insights on
- Improved Antioxidant Defense
- Low evidence
They enhance antioxidant enzymes, neutralize reactive oxygen species, and inhibit lipid peroxidation, thereby protecting tissues from oxidative damage.
Effect
Beneficial
Effect size
Moderate

Bifidobacterium plantarum and Improved Antioxidant Defense

Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.

Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders.

Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance.