Bifidobacterium plantarum and Improved Atopic Dermatitis Symptoms

• The Intervention Effect of Externally Applying or Orally Administering Bifidobacterium animalis Subsp. lactis J12 on Atopic Dermatitis Induced by 2,4-Dinitrofluorobenzene.

  • 2026-01-24
  • Microorganisms 14(2)
  • • Yan Zhang
    • Yixuan Jiang
    • Weilian Hong
    • Shaoyang Ge
    • Nanqing Jing
    • Jianjun Yang
    • Yuanhong Xie
    • Hongxing Zhang
    • Junhua Jin

  • PubMed: 41753561
  • DOI: 10.3390/microorganisms14020274

  5 Insights on

  • Improved Atopic Dermatitis Symptoms

  • Low evidence

  Both J12-derived formulations alleviated DNFB-induced AD symptoms: Topical J12S significantly reduced ear swelling, serum IL-4 and IL-17 levels, and increased the proportion of splenic Treg cells.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Oral administration of Lactiplantibacillus plantarum GKK1 ameliorates atopic dermatitis in a mouse model.

  • 2025-06-03
  • Frontiers in microbiology 16
  • • Tzu-Chun Lin
    • Yu-Chieh Wu
    • You-Shan Tsai
    • Shih-Wei Lin
    • Chin-Chu Chen
    • Ming-Ju Chen
    • Yen-Po Chen

  • PubMed: 40529585
  • DOI: 10.3389/fmicb.2025.1566594

  6 Insights on

  • Improved Atopic Dermatitis Symptoms

  • Low evidence

  Oral L. plantarum GKK1 effectively ameliorated AD symptoms and reduced inflammation in mice. Therefore, L. plantarum GKK1 may serve as a potential treatment for AD.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes