Bifidobacterium plantarum and Improved Gastroesophageal Reflux Symptoms

• Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.

  • 2026-02-17
  • RCT
  • mSystems 11(2)
  • • Yingmeng Li
    • Qiong Li
    • Keyu Quan
    • Yong Xie
    • Ni Yang
    • Teng Ma
    • Longjin Zheng
    • Wei Zhou
    • Yalin Li
    • Hao Jin
    • Zhihong Sun
    • Yongfu Chen
    • Lai-Yu Kwok
    • Nonghua Lu
    • Weifeng Zhu
    • Wenjun Liu
    • Heping Zhang

  • PubMed: 41609355
  • DOI: 10.1128/msystems.01568-25

  8 Insights on

  • Improved Gastroesophageal Reflux Symptoms

  • High evidence
  • Rigorous Journal

  Compared with the placebo group, the probiotic group exhibited a pronounced 36.51% reduction in RDQ scores after 12 weeks of intervention (P = 0.017), alongside a higher numerical endoscopic healing rate (36.84% vs 12.50%; P = 0.365).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes