Across 4 studies, all reported beneficial effects of Bifidobacterium plantarum (often in combination with other strains) on short-chain fatty acid (SCFA) production, with 3 showing statistically significant findings. The predominant effect size was moderate, though one study reported a small effect. Most studies were in vitro fermentation models or animal-derived fecal samples, and no specific dose or population was consistently reported.
Caveats: All four studies are from 2026, have small or unreported sample sizes, and are primarily in vitro or animal-model experiments, limiting generalizability to humans. Three of the four studies used multi-strain interventions, making it difficult to isolate the effect of Bifidobacterium plantarum alone.
Bifidobacterium adolescentis supplementation increased short-chain fatty acids acetate and propionate
Interventions with S131 and Mix significantly increased concentrations of the health-promoting SCFAs, such as acetic acid, propionic acid and butyric acid.
BCL7524 produced significantly (<i>p</i> < 0.05) higher levels of hexanoate (3-14 mM) and valerate (10-15 mM), supporting chain-elongation activity within the community.
chickpea yogurts played a positive role in regulating short-chain fatty acids (SCFAs) levels in vitro fecal fermentation experiments.
accompanied by increased acetate, propionate, and butyrate levels.