Bifidobacterium plantarum and Modulated Nociceptive Signaling

• Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.

  • 2025-11-20
  • Scientific reports 15(1)
  • • Phichaya Suthivanich
    • Sirikorn Vongseenin
    • Vichaya Auvichayapat
    • Weera Supronsinchai
    • Somying Tumwasorn
    • Maneerat Chayanupatkul
    • Saknan Bongsebandhu-Phubhakdi

  • PubMed: 41266742
  • DOI: 10.1038/s41598-025-24928-2

  6 Insights on

  • Modulated Nociceptive Signaling

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Only B.longum prolonged action potential duration and depolarization time (p = 0.0454 and p = 0.034, respectively), suggesting enhanced modulation of nociceptive signaling.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes