Bifidobacterium plantarum and Reduced Anxiety-like Behavior

• Current Evidence from Animal Models on Molecular Changes Underlying Antidepressant Effects of Psychobiotics.

  • 2026-01-22
  • Review
  • Pharmaceutics 18(1)
  • • Nevena Todorović Vukotić
    • Neda Đorđević
    • Andrijana Stanisavljević Ilić
    • Svetlana Soković Bajić
    • Ivana Perić

  • PubMed: 41599247
  • DOI: 10.3390/pharmaceutics18010140

  8 Insights on

  • Reduced Anxiety-like Behavior

  • Low evidence

  psychobiotics show protective effects against depressive- and anxiety-like behaviors in various animal models of depression

  Effect

  Beneficial

  Effect size

  Moderate

• Bifidobacterium longum P77 and Lactiplantibacillus plantarum P72 and Their Mix-Live or Heat-Treated-Mitigate Sleeplessness and Depression in Mice: Involvement of Serotonergic and GABAergic Systems.

  • 2025-10-03
  • Cells 14(19)
  • • Ji-Su Baek
    • Xiaoyang Ma
    • Hee-Seo Park
    • Dong-Yun Lee
    • Dong-Hyun Kim

  • PubMed: 41090775
  • DOI: 10.3390/cells14191547

  8 Insights on

  • Reduced Anxiety-like Behavior

  • Low evidence

  B. longum P77, L. plantarum P72, and their combination decreased cFM- or immobilization stress-induced depression-, anxiety-, and sleeplessness-like behaviors.

  Effect

  Beneficial

  Effect size

  Moderate