Bifidobacterium plantarum and Reduced Cortical Spreading Depression

• Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.

  • 2025-11-20
  • Scientific reports 15(1)
  • • Phichaya Suthivanich
    • Sirikorn Vongseenin
    • Vichaya Auvichayapat
    • Weera Supronsinchai
    • Somying Tumwasorn
    • Maneerat Chayanupatkul
    • Saknan Bongsebandhu-Phubhakdi

  • PubMed: 41266742
  • DOI: 10.1038/s41598-025-24928-2

  6 Insights on

  • Reduced Cortical Spreading Depression

  • Low evidence
  • Rigorous Journal
  • Animal Study

  B.longum significantly reduced CSD frequency (p = 0.0045), while L.plantarum and its combination with B.longum markedly attenuated CSD amplitude (p = 0.0003, p = 0.01, respectively), reflecting suppression of cortical hyperexcitability.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes