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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lacticaseibacillus casei and Reduced Anxiety

Time to effect

Median: 2.9 months · IQR 10.3 weeks–3.5 months · Range 8 weeks–4 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
Although placebo effect cannot be ignored in intervention for VM patients, the probiotic LcS still exhibits considerable efficacy against VM symptoms over a 4 month study period, supporting further clinical study of a larger and more diverse cohort.
from: The probiotic Lactobacillus casei Shirota attenuates symptoms of vestibular migraine: a ra

2 of 2 papersPopulation:

The probiotic Lactobacillus casei Shirota attenuates symptoms of vestibular migraine: a randomised placebo-controlled double-blind clinical trial.
- 2020-09-01
- RCT
- Beneficial microbes 11(5)
- - X Qi
  - G Fan
  - H Jia
- PubMed: 32865025
- DOI: 10.3920/bm2020.0058
6 Insights on
- Reduced Anxiety
- High evidence
- Rigorous Journal
- Clinical
Efficacy of LcS over placebo was not obvious at 2 month follow-up.
Effect
Neutral
Effect size
Small
Significant
No
Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models.
- 2016-02-20
- RCT
- Neurogastroenterology and motility 28(7)
- - M Takada
  - K Nishida
  - A Kataoka-Kato
  - Y Gondo
  - H Ishikawa
  - K Suda
  - M Kawai
  - R Hoshi
  - O Watanabe
  - T Igarashi
  - Y Kuwano
  - K Miyazaki
  - K Rokutan
- PubMed: 26896291
- DOI: 10.1111/nmo.12804
3 Insights on
- Reduced Anxiety
- High evidence
- Highly Cited
- Adults
Subjective anxiety scores ... during the intervention were pooled and analyzed.
Effect
Neutral
Effect size
Small
Significant
No
Dose
daily for 8 weeks