Lactobacillus casei Shirota probiotic drinks reduce antibiotic associated diarrhoea in patients with spinal cord injuries who regularly consume proton pump inhibitors: a subgroup analysis of the ECLISP multicentre RCT.
- 2024-03-22
- RCT · n = 50
- Spinal cord 62(5)
- Samford Wong
- Shashivadan P Hirani
- Alastair Forbes
- Naveen Kumar
- Ramaswamy Hariharan
- Jean O'Driscoll
- Ravi Sekhar
- Ali Jamous
- PubMed: 38519563
- DOI: 10.1038/s41393-024-00983-w
- High evidence
- Clinical
Multivariate logistic regression analysis identified that LcS can reduce the risk of AAD at 30 days (OR: 0.36, 95% CI 0.13, 0.99, p < 0.05).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- at least 6.5 × 10^9 live Lactobacillus casei Shirota (LcS) once daily