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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lacticaseibacillus casei and Reduced Pain

Time to effect

Median: 6 months · IQR 6 months–6 months · Range 6 months–6 months — Reported in 1 of 2 studies

2 of 2 papers

The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial.
- 2017-10-13
- RCT · n = 537
- Beneficial microbes 8(5)
- - M Lei
  - C Guo
  - D Wang
  - C Zhang
  - L Hua
- PubMed: 28726510
- DOI: 10.3920/bm2016.0207
3 Insights on
- Reduced Pain
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
- Clinical
After 6 months of treatment, both WOMAC and VAS scores were significantly improved in the LcS groups of patients compared to the placebo group.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
daily consumption of skimmed milk containing Lactobacillus casei Shirota
The Effect of Probiotics on the Management of Pain and Inflammation in Osteoarthritis: A Systematic Review and Meta-Analysis of Clinical Studies.
- 2024-07-12
- Meta-Analysis · n = 501
- Nutrients 16(14)
- - Maria Moyseos
  - Jenny Michael
  - Nuno Ferreira
  - Antonia Sophocleous
- PubMed: 39064686
- DOI: 10.3390/nu16142243
5 Insights on
- Reduced Pain
- High evidence
- Rigorous Journal
- Clinical
A significant reduction in symptoms across all outcomes measured, except stiffness, was evident with Lactobacillus casei Shirota.
Effect
Beneficial
Effect size
Moderate
Significant
Yes