Lactobacillus acidophilus L-92 and Improved Gut Microbiota Balance

Research synthesisVery low evidenceMixed effect size6 studies · 6 beneficial · 0 neutral · 0 harmful

Across 6 review studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on gut microbiota balance, with effect sizes predominantly small to moderate. Most studies lacked specified doses, durations, and population details, limiting the precision of the finding.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). None of the included studies reported statistically significant findings, and all are review articles rather than primary clinical trials, which weakens the causal evidence. Evidence base is small (only 6 studies) — conclusions should be considered preliminary.

Generated May 12, 2026

6 of 6 papers

Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.
- 2025-05-27
- Review
- International journal of molecular sciences 26(11)
- - Zofia Gorzelanna
  - Aleksandra Mamrot
  - Daria Będkowska
  - Joanna Bubak
  - Marta Miszczak
- PubMed: 40507953
- DOI: 10.3390/ijms26115143
8 Insights on
- Improved Gut Microbiota Balance
- Moderate evidence
- Rigorous Journal
The health benefits of animal-derived probiotic strains include improved digestion, balanced microbiota, behavioral impact, reduced inflammation, and minimized risk of infections.
Effect
Beneficial
Effect size
Moderate
Lactic Acid Bacteria as the Green and Safe Food Preservatives: Their Mechanisms, Applications and Prospects.
- 2026-01-09
- Review
- Foods (Basel, Switzerland) 15(2)
- - Yuwei Zhang
  - Lianrui Li
  - Xiaoyang Pang
  - Shuwen Zhang
  - Yang Liu
  - Yunna Wang
  - Ning Xie
  - Xu Li
- PubMed: 41596840
- DOI: 10.3390/foods15020241
6 Insights on
- Improved Gut Microbiota Balance
- Low evidence
Lactobacillus acidophilus L-92 may contribute to health by modulating intestinal microbiota and enhancing the host immune response.
Effect
Beneficial
Effect size
Small
Probiotics and Phytoantioxidants Target Coronary Endothelial Dysfunction in Irregular Sleep- and Obesity-Associated Cardiometabolic Syndrome.
- 2025-11-12
- Review
- Life (Basel, Switzerland) 15(11)
- - Chi-Nan Tseng
  - Yen Chu
- PubMed: 41302164
- DOI: 10.3390/life15111740
3 Insights on
- Improved Gut Microbiota Balance
- Low evidence
Clinical evidence indicates that probiotics restore microbial equilibrium and attenuate vascular damage.
Effect
Beneficial
Effect size
Small
Natural Molecules, Nutraceuticals, and Engineered Nanosystems: A Comprehensive Strategy for Combating Gardnerella vaginalis-Induced Bacterial Vaginosis.
- 2025-10-21
- Review
- Microorganisms 13(10)
- - Manoj Dalabehera
  - Abdulrahman Mohammed Alhudhaibi
  - Emad M Abdallah
  - Tarek H Taha
  - Shubham Chaudhari
  - Alka Kumari
  - Rudra Narayan Subudhi
  - Charul Rathore
- PubMed: 41156869
- DOI: 10.3390/microorganisms13102411
2 Insights on
- Improved Gut Microbiota Balance
- Low evidence
restoring vaginal microbial balance
Effect
Beneficial
Effect size
Moderate
Application of Probiotics in Cats and Dogs: Benefits and Mechanisms.
- 2025-10-17
- Review
- Veterinary sciences 12(10)
- - Jintao Sun
  - Xinshu Gu
  - Huaiyu Zhang
  - Lihong Zhao
  - Jinquan Wang
  - Xiumin Wang
  - Hui Tao
  - Zhenlong Wang
  - Bing Han
- PubMed: 41150148
- DOI: 10.3390/vetsci12101008
14 Insights on
- Improved Gut Microbiota Balance
- Low evidence
regulating gut microbiota balance
Effect
Beneficial
Effect size
Moderate
Optimizing chronic kidney disease management: The potential of a multi-strain probiotic formulation.
- 2025-03-25
- Review
- World journal of nephrology 14(1)
- - Deodatta Chafekar
- PubMed: 40134645
- DOI: 10.5527/wjn.v14.i1.101515
6 Insights on
- Improved Gut Microbiota Balance
- Low evidence
Specific probiotic strains, including Lactobacillus and Bifidobacterium, promote beneficial bacterial growth, suppress harmful bacteria, and exert anti-inflammatory, antihypertensive, and antidiabetic effects.
Effect
Beneficial
Effect size
Small

Lactobacillus acidophilus L-92 and Improved Gut Microbiota Balance

Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.

Lactic Acid Bacteria as the Green and Safe Food Preservatives: Their Mechanisms, Applications and Prospects.

Probiotics and Phytoantioxidants Target Coronary Endothelial Dysfunction in Irregular Sleep- and Obesity-Associated Cardiometabolic Syndrome.

Natural Molecules, Nutraceuticals, and Engineered Nanosystems: A Comprehensive Strategy for Combating Gardnerella vaginalis-Induced Bacterial Vaginosis.

Application of Probiotics in Cats and Dogs: Benefits and Mechanisms.

Optimizing chronic kidney disease management: The potential of a multi-strain probiotic formulation.