Lactobacillus acidophilus L-92 and Improved Insulin Sensitivity

• Effects of probiotic and metformin co-administration versus metformin monotherapy on anthropometric measurements, hormones, and glucolipid profile in women with polycystic ovary syndrome: a systematic review and meta-analysis.

  • 2026-03-26
  • Meta-Analysis
  • Frontiers in endocrinology 17
  • • Mohammed Hamsho
    • Wijdan Shkorfu
    • Meriem Bensaoua
    • Carlos Eduardo Carvalho Martins
    • Hale Hacıbayram
    • Abdulmannan Fadel
    • Yazan Ranneh

  • PubMed: 41970993
  • DOI: 10.3389/fendo.2026.1802369

  4 Insights on

  • Improved Insulin Sensitivity

  • High evidence

  compared to metformin alone the addition of probiotics decreased insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR): MD -0.50, 95% CI -0.73 to -0.26; low-to-moderate heterogeneity)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

  • 2026-01-08
  • Review
  • Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 37(2)
  • • Anoohya Gandham
    • Konstantinos Prokopidis
    • Costas Glavas
    • David Scott
    • Mattias Lorentzon

  • PubMed: 41507594
  • DOI: 10.1007/s00198-025-07801-w

  4 Insights on

  • Improved Insulin Sensitivity

  • Low evidence

  Probiotics, containing live beneficial microorganisms, have shown potential in enhancing SCFA production, reducing inflammation, and improving insulin sensitivity.

  Effect

  Beneficial

  Effect size

  Small