Lactobacillus acidophilus L-92 and Reduced Depression Symptoms

• "Attacking" the Gut-Brain Axis with Psychobiotics: An Umbrella Review of Depressive and Anxiety Symptoms.

  • 2026-01-15
  • Review
  • Pharmaceuticals (Basel, Switzerland) 19(1)
  • • Alberto Souza Sá Filho
    • Tatiane Bastos Souza
    • José Luís Rodrigues Martins
    • Gunnar P H Dietz
    • Katia Flávia Fernandes
    • Stone de Sá
    • Pedro Augusto Inacio
    • Iransé Oliveira-Silva
    • Gustavo Pedrino
    • Vicente Aprigliano
    • Gaspar R Chiappa
    • James Oluwagbamigbe Fajemiroye

  • PubMed: 41599756
  • DOI: 10.3390/ph19010156

  2 Insights on

  • Reduced Depression Symptoms

  • Low evidence

  Probiotic interventions demonstrated consistent benefits for MDD (SMD = -0.50 [95% CI: -0.58 to -0.42], p = 0.0001).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes