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Evidence-Based Supplement Research
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Lactobacillus acidophilus L-92 and Reduced Inflammation

Research synthesisModerate evidenceSmall effect9 studies · 9 beneficial · 0 neutral · 0 harmful

Across 9 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on reducing inflammation, with effect sizes ranging from small to moderate. The most robust evidence comes from a large meta-analysis (n=3390) in subjects with type 2 diabetes, showing small beneficial effects on inflammatory markers such as C-reactive protein and tumor necrosis factor alpha. A single small randomized controlled trial in underweight participants reported statistically significant moderate reductions in inflammatory markers (ESR, CRP).

  • Studied populations: subjects with type 2 diabetes, underweight participants

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (beneficial results are more likely to be published or indexed). Only 1 of 9 studies reported statistically significant findings, suggesting the observed benefits may be smaller or less consistent than the effect direction implies. Study durations were not consistently reported, and dose information was absent across all studies, limiting practical guidance.

Generated Jun 11, 2026
9 of 9 papers
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