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Evidence-Based Supplement Research
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Lactobacillus acidophilus La-14 and Reduced Inflammation

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus acidophilus La-14 on reduced inflammation, with moderate effect sizes observed in two studies and a small effect in one. Most evidence comes from studies on women with gestational diabetes mellitus (GDM). The evidence base is very small and no studies reported statistically significant results, so conclusions are preliminary.

  • Studied populations: women with gestational diabetes mellitus (GDM); one study in a mouse model of colitis

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jun 11, 2026
3 of 3 papers
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