Lactobacillus acidophilus LA1 and Improved Intestinal Barrier Function

• Probiotics and the intestinal tight junction barrier function.

  • 2025-12-01
  • Review
  • Frontiers in cell and developmental biology 13
  • • Megan M Ferris
    • Ligia Subitoni Antonio
    • Rana Al-Sadi

  • PubMed: 41403703
  • DOI: 10.3389/fcell.2025.1671152

  1 Insight on

  • Improved Intestinal Barrier Function

  • Low evidence

  Specific strains of Lactobacillus, Bifidobacterium, Escherichia coli Nissle 1917, Bacillus subtilis, and Saccharomyces boulardii have been shown to enhance barrier integrity in cell culture, animal models, and in some clinical settings. These probiotics exert their effects through diverse mechanisms, including the upregulation of TJ proteins (e.g., occludin, claudins, ZO-1)

  Effect

  Beneficial

  Effect size

  Moderate