Irritable bowel syndrome symptom severity improves equally with probiotic and placebo
- 2017-06-06
- RCT · n = 340
- World Journal of Gastroenterology 22(48)
- Anna Lyra
- M. Hillilä
- T. Huttunen
- Sofia Männikkö
- M. Taalikka
- Julia Tennilä
- A. Tarpila
- S. Lahtinen
- A. Ouwehand
- L. Veijola
- PubMed: 28082816
- DOI: 10.3748/wjg.v22.i48.10631
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
In a post hoc analysis of volunteers with moderate to severe abdominal pain at baseline (VAS > 35/100), the treatment significantly reduced the sensation of abdominal pain. Pain scores fell by 20.8 ± 22.8, 29.4 ± 17.9, and 31.2 ± 21.9 in the placebo, active low-dose, and active high-dose groups, respectively (P value for placebo vs combined active doses = 0.0460).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 10^9 or 10^10 CFU/day