Lactobacillus acidophilus NCFM and Reduced Intestinal Inflammation

• A Synbiotic Combining Chitin-Glucan and Lactobacillus acidophilus NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an Animal Model of IBS.

  • 2024-10-05
  • International journal of molecular sciences 25(19)
  • • Lena Capirchio
    • Christel Rousseaux
    • Caroline Dubuquoy
    • Arthur C Ouwehand
    • Véronique Maquet
    • Salvatore Modica
    • Edouard Louis
    • Pierre Desreumaux
    • Jan Tack

  • PubMed: 39409061
  • DOI: 10.3390/ijms251910732

  2 Insights on

  • Reduced Intestinal Inflammation

  • Low evidence
  • Rigorous Journal
  • Animal Study

  This synbiotic treatment significantly reduced macroscopic colonic lesions and MPO concentrations, and induced master genes involved in analgesia (CB1, CB2, MOR, PPARα), with a downregulation of inflammatory cytokines (IL-1β, TNFα) and an induction of IL-10 and PPARγ.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes