Lactobacillus amylovorus and Reduced Oxidative Stress

• Serum CA19-9 and CEA levels, serum CAT, GSH, oxidised glutathione levels, 8-dihidro-2'-deoksiguanosina and F2-isoprostanes levels in colorectal cancer patients and Lactobacillus: A randomised double-blind controlled trial.

  • 2025-11-24
  • RCT · n = 76
  • Journal of medical biochemistry 44(7)
  • • Shiru Chen
    • Weili Ning
    • Jiye Zhang
    • Zhenting Wu
    • Hang Zhou
    • Ying Liu

  • PubMed: 41281285
  • DOI: 10.5937/jomb0-56528

  16 Insights on

  • Reduced Oxidative Stress

  • High evidence

  Lactobacillus supplementation ... reduced OS marker levels and inhibited NRF2/KEAP1, p38 MAPK, and JNK signalling pathways in CRC patients after surgery.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Probiotic-derived extracellular vesicles attenuate cholestatic liver damage via gut-liver axis.

  • 2026-03
  • Pharmacological research 225
  • • Xianjiao Liu
    • Yanyan Wang
    • Andrea Abreo Medina
    • Dandan Liu
    • Jinyan Liu
    • Wenxuan Tang
    • Mengmeng Wang
    • Xingxiang Chen
    • Kehe Huang
    • Min Liu
    • Chunfeng Wang
    • Yunhuan Liu

  • PubMed: 41747917
  • DOI: 10.1016/j.phrs.2026.108152

  3 Insights on

  • Reduced Oxidative Stress

  • Low evidence
  • Animal Study

  LAEVs... reduced liver BAs and oxidative stress level, which ultimately mitigated liver damage and fibrosis.

  Effect

  Beneficial

  Effect size

  Moderate