The beneficial effect of probiotics in the prevention of irinotecan-induced diarrhea in colorectal cancer patients with colostomy: a pooled analysis of two probiotic trials (Probio-SK-003 and Probio-SK-005) led by Slovak Cooperative Oncology Group.
- 2024-07-22
- RCT · n = 279
- Frontiers in oncology 14
- Michal Mego
- Barbora Kasperova
- Jozef Chovanec
- Radoslav Danis
- Maria Reckova
- Branislav Bystricky
- Peter Konkolovsky
- Silvia Jurisova
- Stefan Porsok
- Vladimir Vaclav
- Maria Wagnerova
- Marian Stresko
- Bibiana Brezinova
- Dagmar Sutekova
- Sona Ciernikova
- Daniela Svetlovska
- Lubos Drgona
- PubMed: 39104721
- DOI: 10.3389/fonc.2024.1438657
- High evidence
subgroup analysis revealed that patients with a colostomy who received a placebo had a significantly higher incidence of any diarrhea (placebo 51.2% vs. probiotics 25.7%, p = 0.028) and grade 3/4 diarrhea (placebo 14.6% vs. probiotics 0.0%, p = 0.03) compared to the probiotic arm.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes