Lactobacillus brevis MAK11L82B and Reduced Colitis Symptoms

• Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model

  • 2019-09-18
  • RCT
  • Frontiers in Physiology 10
  • • Sujuan Ding
    • Yong Ma
    • Gang Liu
    • Wenxin Yan
    • Hongmei Jiang
    • Jun Fang

  • PubMed: 31620010
  • DOI: 10.3389/fphys.2019.01152

  16 Insights on

  • Reduced Colitis Symptoms

  • Low evidence
  • Animal Study

  Our results demonstrate that *L. brevis* treatment significantly alleviated DSS-induced body weight loss and colon inflammation.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Lactobacillus brevis G‐101 ameliorates colitis in mice by inhibiting NF‐κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2‐like macrophages

  • 2013-07-01
  • Clinical Trial
  • Journal of Applied Microbiology 115(3)
  • • Se-Eun Jang
    • S. Hyam
    • M. Han
    • S. Kim
    • B.G. Lee
    • Dong-Hyun Kim

  • PubMed: 23742179
  • DOI: 10.1111/jam.12273

  3 Insights on

  • Reduced Colitis Symptoms

  • Low evidence
  • Highly Cited
  • Animal Study

  Lactobacillus brevis G-101 may improve colitis by inhibiting the IRAK1/NF-κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes