Lactobacillus brevis SBC8803 and Improved Gastric Mucosal Protection

• Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.

  • 2019-08-10
  • International journal of molecular sciences 20(16)
  • • Ghalia Khoder
    • Farah Al-Yassir
    • Asma Al Menhali
    • Prashanth Saseedharan
    • Subi Sugathan
    • Catherine Tomasetto
    • Sherif M Karam

  • PubMed: 31405107
  • DOI: 10.3390/ijms20163901

  4 Insights on

  • Improved Gastric Mucosal Protection

  • Low evidence
  • Rigorous Journal
  • Animal Study

  treated mice acquired (i) increased production of mucus, trefoil factor (TFF) 1 and TFF2, (ii) decreased production of pepsinogen, and (iii) increased ghrelin-secreting cells. ... Therefore, VSL#3 administration amplifies specific cell types specialized in the protection of the gastric epithelium.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes