Across 5 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on skin barrier function, with effect sizes predominantly small. One meta-analysis found a statistically significant small effect on reducing trans-epidermal water loss (pSMD = -0.50, p = 6.39 × 10⁻⁴). Doses were not reported in the available studies, and the evidence primarily comes from reviews and a meta-analysis covering general healthy adults and some patient populations.
Caveats: Only one study (a meta-analysis) provides a statistically significant finding with a reported effect size; the remaining four are narrative reviews with no original quantitative data. Doses are not specified in any included study. Evidence is largely indirect or preliminary, and most studies are not specifically focused on Lactobacillus brevis SBC8803 but rather on probiotics or dietary interventions more broadly.
polyphenols strengthen barrier integrity (trans-epidermal water loss pSMD = - 0.50 [- 0.79, - 0.22], p = 6.39 × 10-4)
consuming Lactobacillus brevis SBC8803 was associated with improved skin barrier function in healthy adult humans
studies have substantiated their efficacy in enhancing hydration, reducing wrinkles, and fortifying barrier integrity
consuming Lactobacillus brevis SBC8803
There is preliminary evidence that certain probiotics given orally or topically could be used as a gentle intervention in diaper dermatitis.
Administration of HK-SBC8803 in the first three experiments caused marked inhibition of CASNA and significant elevation of cutaneous blood flow under urethane anaesthesia as well as significant decrease in TEWL on the dorsal skin of conscious hairless rats.