Across 5 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on skin barrier function, with effect sizes predominantly small. One meta-analysis found a statistically significant small effect on trans-epidermal water loss (pSMD = -0.50, p = 6.39 × 10⁻⁴). The evidence base is limited and most studies are reviews; no consistent dose, form, or study duration data were reported.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies are narrative reviews rather than original trials, and only 1 of 5 studies reported a statistically significant finding. Evidence base is small (only 5 studies) — conclusions should be considered preliminary.
polyphenols strengthen barrier integrity (trans-epidermal water loss pSMD = - 0.50 [- 0.79, - 0.22], p = 6.39 × 10-4)
consuming Lactobacillus brevis SBC8803 was associated with improved skin barrier function in healthy adult humans
studies have substantiated their efficacy in enhancing hydration, reducing wrinkles, and fortifying barrier integrity
consuming Lactobacillus brevis SBC8803
There is preliminary evidence that certain probiotics given orally or topically could be used as a gentle intervention in diaper dermatitis.
Administration of HK-SBC8803 in the first three experiments caused marked inhibition of CASNA and significant elevation of cutaneous blood flow under urethane anaesthesia as well as significant decrease in TEWL on the dorsal skin of conscious hairless rats.