Across 5 studies, all 5 reported beneficial effects on skin barrier function, with predominantly small effect sizes. One meta-analysis found a statistically significant small effect on trans-epidermal water loss, but its relevance to Lactobacillus brevis SBC8803 is uncertain as the analysis focused on polyphenols. The evidence base is limited to reviews and a single meta-analysis, with no consistent dose or duration data reported.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Additionally, the only statistically significant study (a meta-analysis) reported effects of polyphenols, not specifically Lactobacillus brevis SBC8803, casting doubt on the direct applicability of that finding. Most studies are narrative reviews, and no dose or form information is available.
polyphenols strengthen barrier integrity (trans-epidermal water loss pSMD = - 0.50 [- 0.79, - 0.22], p = 6.39 × 10-4)
consuming Lactobacillus brevis SBC8803 was associated with improved skin barrier function in healthy adult humans
studies have substantiated their efficacy in enhancing hydration, reducing wrinkles, and fortifying barrier integrity
consuming Lactobacillus brevis SBC8803
There is preliminary evidence that certain probiotics given orally or topically could be used as a gentle intervention in diaper dermatitis.
Administration of HK-SBC8803 in the first three experiments caused marked inhibition of CASNA and significant elevation of cutaneous blood flow under urethane anaesthesia as well as significant decrease in TEWL on the dorsal skin of conscious hairless rats.