Lactobacillus brevis SBC8803 and Reduced Body Fat

Research synthesisLow evidenceSmall effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 available studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on reduced body fat, with effect sizes ranging from small to moderate. A 2025 meta-analysis (n=58) found a statistically significant small reduction in body fat (MD: -1.11; 95%CI: -1.31 to -0.91; p<0.00001) in obese individuals without comorbidities. The limited body of evidence shows consistent direction but the most robust finding is small in magnitude.

Studied populations: obese individuals without comorbidities

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Only one study provided a quantitative effect estimate with statistical significance; the remaining studies are narrative reviews with no primary data or confidence intervals.

Generated Jun 11, 2026

4 of 4 papers

Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.
- 2025-04-23
- Meta-Analysis · n = 58
- Narra J 5(2)
- - Juan Ajmn Lele
  - Karlos B Sihaloho
  - Dewa Vighneshwara
  - Derren Dch Rampengan
  - Chrisandi Y Rizqiansyah
  - Happy K Permatasari
  - Nelly Mayulu
  - Trina E Tallei
  - Nurpudji A Taslim
  - Bonglee Kim
  - Immanuelle Kezia
  - Fahrul Nurkolis
  - Rony A Syahputra
- PubMed: 40951500
- DOI: 10.52225/narra.v5i2.1562
9 Insights on
- Reduced Body Fat
- High evidence
Additionally, compared to control group, significant reductions were observed in visceral and subcutaneous fat mass ... and overall body fat (MD: -1.11; 95%CI: -1.31-(-0.91); p<0.00001)
Effect
Beneficial
Effect size
Small
Significant
Yes
Role of Intestinal Microbes in Chronic Liver Diseases.
- 2022-10-21
- Review
- International journal of molecular sciences 23(20)
- - Mengyi Xu
  - Kangkang Luo
  - Junjie Li
  - Yu Li
  - Yuxuan Zhang
  - Zhiyao Yuan
  - Qiang Xu
  - Xudong Wu
- PubMed: 36293518
- DOI: 10.3390/ijms232012661
3 Insights on
- Reduced Body Fat
- Moderate evidence
- Rigorous Journal
consuming Lactobacillus brevis SBC8803 ... showed a significant decrease in body fat percentage compared with placebo
Effect
Beneficial
Effect size
Moderate
Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications.
- 2021-02-20
- Review
- Molecules (Basel, Switzerland) 26(4)
- - Alka Rani
  - Khem Chand Saini
  - Felix Bast
  - Sanjeet Mehariya
  - Shashi Kant Bhatia
  - Roberto Lavecchia
  - Antonio Zuorro
- PubMed: 33672774
- DOI: 10.3390/molecules26041142
4 Insights on
- Reduced Body Fat
- Low evidence
Lactobacillus brevis SBC8803 has been shown to reduce body fat in healthy adults.
Effect
Beneficial
Effect size
Moderate
Precision medicine in alcoholic and nonalcoholic fatty liver disease via modulating the gut microbiota.
- 2016-12-01
- Review
- American journal of physiology. Gastrointestinal and liver physiology 311(6)
- - Sena Bluemel
  - Brandon Williams
  - Rob Knight
  - Bernd Schnabl
- PubMed: 27686615
- DOI: 10.1152/ajpgi.00245.2016
4 Insights on
- Reduced Body Fat
- Low evidence
Products secreted by Lactobacillus- and microbiota-derived metabolites, such as fatty acids and antioxidants, that could be used for precision medicine in the treatment of liver disease.
Effect
Beneficial
Effect size
Small

Lactobacillus brevis SBC8803 and Reduced Body Fat

Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.

Role of Intestinal Microbes in Chronic Liver Diseases.

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications.

Precision medicine in alcoholic and nonalcoholic fatty liver disease via modulating the gut microbiota.