Lactobacillus brevis SBC8803 and Reduced Body Fat

Research synthesisLow evidenceSmall effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all 4 reported beneficial effects on reduced body fat, with effect sizes ranging from small to moderate. The highest-quality evidence comes from a 2025 meta-analysis of 58 obese individuals, which found a statistically significant small reduction in overall body fat (MD: -1.11; 95%CI: -1.31-(-0.91); p<0.00001). Two narrative reviews also report beneficial effects, but with limited detail on dose and population.

Studied populations: obese individuals without comorbidities

Caveats: Only one study (the meta-analysis) provides high-quality evidence; the remaining three are narrative reviews with limited methodological detail and no reported sample sizes or doses. The evidence base is sparse, and the clinical significance of the small effect size in the meta-analysis should be interpreted cautiously.

Generated May 11, 2026

4 of 4 papers

Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.
- 2025-04-23
- Meta-Analysis · n = 58
- Narra J 5(2)
- - Juan Ajmn Lele
  - Karlos B Sihaloho
  - Dewa Vighneshwara
  - Derren Dch Rampengan
  - Chrisandi Y Rizqiansyah
  - Happy K Permatasari
  - Nelly Mayulu
  - Trina E Tallei
  - Nurpudji A Taslim
  - Bonglee Kim
  - Immanuelle Kezia
  - Fahrul Nurkolis
  - Rony A Syahputra
- PubMed: 40951500
- DOI: 10.52225/narra.v5i2.1562
9 Insights on
- Reduced Body Fat
- High evidence
Additionally, compared to control group, significant reductions were observed in visceral and subcutaneous fat mass ... and overall body fat (MD: -1.11; 95%CI: -1.31-(-0.91); p<0.00001)
Effect
Beneficial
Effect size
Small
Significant
Yes
Role of Intestinal Microbes in Chronic Liver Diseases.
- 2022-10-21
- Review
- International journal of molecular sciences 23(20)
- - Mengyi Xu
  - Kangkang Luo
  - Junjie Li
  - Yu Li
  - Yuxuan Zhang
  - Zhiyao Yuan
  - Qiang Xu
  - Xudong Wu
- PubMed: 36293518
- DOI: 10.3390/ijms232012661
3 Insights on
- Reduced Body Fat
- Moderate evidence
- Rigorous Journal
consuming Lactobacillus brevis SBC8803 ... showed a significant decrease in body fat percentage compared with placebo
Effect
Beneficial
Effect size
Moderate
Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications.
- 2021-02-20
- Review
- Molecules (Basel, Switzerland) 26(4)
- - Alka Rani
  - Khem Chand Saini
  - Felix Bast
  - Sanjeet Mehariya
  - Shashi Kant Bhatia
  - Roberto Lavecchia
  - Antonio Zuorro
- PubMed: 33672774
- DOI: 10.3390/molecules26041142
4 Insights on
- Reduced Body Fat
- Low evidence
Lactobacillus brevis SBC8803 has been shown to reduce body fat in healthy adults.
Effect
Beneficial
Effect size
Moderate
Precision medicine in alcoholic and nonalcoholic fatty liver disease via modulating the gut microbiota.
- 2016-12-01
- Review
- American journal of physiology. Gastrointestinal and liver physiology 311(6)
- - Sena Bluemel
  - Brandon Williams
  - Rob Knight
  - Bernd Schnabl
- PubMed: 27686615
- DOI: 10.1152/ajpgi.00245.2016
4 Insights on
- Reduced Body Fat
- Low evidence
Products secreted by Lactobacillus- and microbiota-derived metabolites, such as fatty acids and antioxidants, that could be used for precision medicine in the treatment of liver disease.
Effect
Beneficial
Effect size
Small

Lactobacillus brevis SBC8803 and Reduced Body Fat

Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.

Role of Intestinal Microbes in Chronic Liver Diseases.

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications.

Precision medicine in alcoholic and nonalcoholic fatty liver disease via modulating the gut microbiota.