Lactobacillus casei PXN 37 and Improved Quality of Life

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 systematic reviews, all reported beneficial effects of Lactobacillus casei PXN 37 on quality of life, with predominantly moderate effect sizes. However, none of the included studies reported statistically significant findings, and doses, forms, and durations were not consistently described. The evidence base is small and preliminary.

Studied populations: Patient populations with colorectal cancer undergoing chemotherapy, neurodegenerative diseases (Alzheimer's, Parkinson's, multiple sclerosis, mild cognitive impairment), and gastrointestinal diseases.

Caveats: Available evidence is overwhelmingly positive (3 of 3 studies beneficial), but the evidence base is small and subject to publication bias. None of the included reviews reported statistically significant findings for quality of life improvements, suggesting the effect may be smaller than the predominant direction indicates. Doses and forms were not specified, and study populations varied widely.

Generated Jul 12, 2026

3 of 3 papers

Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review.
- 2023-03-01
- Systematic Review
- Iranian journal of medical sciences 48(2)
- - Reza Mahdavi
  - Elnaz Faramarzi
  - Zeinab Nikniaz
  - Fatemeh FarshiRadvar
- PubMed: 36895464
- DOI: 10.30476/ijms.2022.92793.2411
5 Insights on
- Improved Quality of Life
- High evidence
Another study reported that synbiotic supplementation improved quality of life and marginally reduced diarrhea and serum levels of high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase (MMP-2 and MMP-9).
Effect
Beneficial
Effect size
Small
Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.
- 2024-12-10
- Review
- International journal of general medicine 17
- - Fengya Zhu
  - Shao Yin
  - Yuan Wang
  - Yue Zhong
  - Qiang Ji
  - Jie Wu
- PubMed: 39678681
- DOI: 10.2147/ijgm.s499406
7 Insights on
- Improved Quality of Life
- Low evidence
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health
Effect
Beneficial
Effect size
Moderate
The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.
- 2024-09-30
- Review
- Preventive nutrition and food science 29(3)
- - Jalal Moludi
  - Amir Saber
  - Morteza Arab Zozani
  - Shima Moradi
  - Yasaman Azamian
  - Salimeh Hajiahmadi
  - Yahya Pasdar
  - Fardin Moradi
- PubMed: 39371511
- DOI: 10.3746/pnf.2024.29.3.237
1 Insight on
- Improved Quality of Life
- Low evidence
24 studies reported improvements... on QoL in GI patients supplemented with probiotics. We found that probiotics may improve the QoL of patients with GI diseases and related metabolic complications.
Effect
Beneficial
Effect size
Moderate

Lactobacillus casei PXN 37 and Improved Quality of Life

Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review.

Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.

The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.