Research synthesisVery low evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful
Across 3 studies (all systematic reviews), all reported beneficial effects of Lactobacillus casei PXN 37 (often as part of synbiotic or probiotic supplementation) on quality of life. Effect sizes were mixed (small to moderate), with the highest-quality study (evidence score 4) reporting a small beneficial effect in colorectal cancer patients undergoing chemotherapy. No consistent dose, form, or study duration data were available. The evidence base is very small and preliminary.
- Studied populations: CRC patients undergoing chemotherapy; patients with neurodegenerative diseases (Alzheimer's, Parkinson's, multiple sclerosis, mild cognitive impairment); GI patients
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All three studies are reviews, not original RCTs, and none reported individual statistical significance for the specific strain-outcome pair. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Doses, forms, and treatment durations were not consistently reported, limiting precision of recommendations.
Generated May 12, 2026