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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Lactobacillus casei PXN 37 and Improved Quality of Life

Research synthesisVery low evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus casei PXN 37 on quality of life, with effect sizes ranging from small to moderate. The evidence is derived from systematic reviews in patient populations with colorectal cancer undergoing chemotherapy, neurodegenerative diseases, and gastrointestinal diseases, but no statistically significant findings were reported and study durations were not consistently provided.

  • Studied populations: CRC patients undergoing chemotherapy; patients with neurodegenerative diseases (AD, PD, MS, MCI); GI patients

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. No specific dose, form, or duration data were reported in the included reviews.

Generated Jun 11, 2026
3 of 3 papers
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