Lactobacillus casei PXN 37 and Improved Quality of Life

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 review-level studies, all reported beneficial effects of Lactobacillus casei PXN 37 on quality of life, with effect sizes ranging from small to moderate. The predominant effect size was moderate, observed in two of the three reviews. The most studied populations were colorectal cancer patients undergoing chemotherapy, patients with neurodegenerative diseases, and patients with gastrointestinal diseases. No specific dose range was reported across studies.

Studied populations: CRC patients undergoing chemotherapy, patients with neurodegenerative diseases (AD, PD, MS, and MCI), GI patients

Caveats: All three studies are systematic reviews, but none reported statistically significant findings for quality of life specifically, and none provided sample sizes or dose details for Lactobacillus casei PXN 37. The evidence is based on reviews that included this probiotic among others, so the specific contribution of Lactobacillus casei PXN 37 is unclear.

Generated May 10, 2026

3 of 3 papers

Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review.
- 2023-03-01
- Systematic Review
- Iranian journal of medical sciences 48(2)
- - Reza Mahdavi
  - Elnaz Faramarzi
  - Zeinab Nikniaz
  - Fatemeh FarshiRadvar
- PubMed: 36895464
- DOI: 10.30476/ijms.2022.92793.2411
5 Insights on
- Improved Quality of Life
- High evidence
Another study reported that synbiotic supplementation improved quality of life and marginally reduced diarrhea and serum levels of high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase (MMP-2 and MMP-9).
Effect
Beneficial
Effect size
Small
Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.
- 2024-12-10
- Review
- International journal of general medicine 17
- - Fengya Zhu
  - Shao Yin
  - Yuan Wang
  - Yue Zhong
  - Qiang Ji
  - Jie Wu
- PubMed: 39678681
- DOI: 10.2147/ijgm.s499406
7 Insights on
- Improved Quality of Life
- Low evidence
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health
Effect
Beneficial
Effect size
Moderate
The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.
- 2024-09-30
- Review
- Preventive nutrition and food science 29(3)
- - Jalal Moludi
  - Amir Saber
  - Morteza Arab Zozani
  - Shima Moradi
  - Yasaman Azamian
  - Salimeh Hajiahmadi
  - Yahya Pasdar
  - Fardin Moradi
- PubMed: 39371511
- DOI: 10.3746/pnf.2024.29.3.237
1 Insight on
- Improved Quality of Life
- Low evidence
24 studies reported improvements... on QoL in GI patients supplemented with probiotics. We found that probiotics may improve the QoL of patients with GI diseases and related metabolic complications.
Effect
Beneficial
Effect size
Moderate

Lactobacillus casei PXN 37 and Improved Quality of Life

Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review.

Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.

The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.