Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.

2024-12-10
International journal of general medicine 17
- Fengya Zhu
- Shao Yin
- Yuan Wang
- Yue Zhong
- Qiang Ji
- Jie Wu

PubMed: 39678681
DOI: 10.2147/ijgm.s499406

Study Design

Type: Review
Population: patients with neurodegenerative diseases (AD, PD, MS, and MCI)
Methods: systematic review conducted a detailed search of the Cochrane Library, Embase, PubMed, and Web of Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with intervention durations ranging from 4 to 16 weeks

In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects of probiotics on clinical symptoms and systemic inflammation regulation in various NDDs, this systematic review conducted a detailed search of the Cochrane Library, Embase, PubMed, and Web of Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs for Alzheimer's Disease (AD), 10 RCTs for Parkinson's Disease (PD), 2 RCTs for Multiple Sclerosis (MS), and 2 RCTs for Mild Cognitive Impairment (MCI), and intervention durations ranging from 4 to 16 weeks. The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health. Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients. In conclusion, existing evidence supports the promising potential of probiotics in treating NDDs. However, further large-scale, high-quality studies are needed to explore specific differences in efficacy among various probiotic strains, dosages, and modes of administration. Moreover, considering that lifestyle and dietary habits may modulate the effects of probiotics, these external factors should also be included in research considerations to gain a more comprehensive understanding of the mechanisms and application strategies of probiotics in NDDs treatment.

Research Insights

Bifidobacterium bifidum Bb-02→Improved Cognitive Function
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function
Effect
Beneficial
Effect size
Moderate
Bifidobacterium bifidum Bb-02→Improved Gastrointestinal Function
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function
Effect
Beneficial
Effect size
Moderate
Bifidobacterium bifidum Bb-02→Improved Mental Health
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health
Effect
Beneficial
Effect size
Moderate
Bifidobacterium bifidum Bb-02→Improved Quality of Life
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health
Effect
Beneficial
Effect size
Moderate
Bifidobacterium bifidum Bb-02→Increased Antioxidant Capacity
probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Small
Bifidobacterium bifidum Bb-02→Reduced Inflammation
Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium lactis Bb-02→Improved Neurodegenerative Disease Symptoms
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium lactis Bb-02→Increased Antioxidant Capacity
probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Small
Bifidobacterium lactis Bb-02→Reduced Inflammation
Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Moderate
Lactobacillus casei PXN 37→Improved Cognitive Function
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function
Effect
Beneficial
Effect size
Moderate
Lactobacillus casei PXN 37→Improved Gastrointestinal Function
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function
Effect
Beneficial
Effect size
Moderate
Lactobacillus casei PXN 37→Improved Mental Health
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health
Effect
Beneficial
Effect size
Moderate
Lactobacillus casei PXN 37→Improved Quality of Life
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health
Effect
Beneficial
Effect size
Moderate
Lactobacillus casei PXN 37→Increased Antioxidant Capacity
probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Small
Lactobacillus casei PXN 37→Reduced Inflammation
Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus HA-114→Improved Neurodegenerative Disease Symptoms
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus HA-114→Increased Antioxidant Capacity
probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Small
Lactobacillus rhamnosus HA-114→Reduced Inflammation
Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus PXN 54→Improved Neurodegenerative Disease Symptoms
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus PXN 54→Reduced Inflammation
Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Moderate
Streptococcus thermophilus PXN 66→Improved Neurodegenerative Disease Symptoms
The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health.
Effect
Beneficial
Effect size
Moderate
Streptococcus thermophilus PXN 66→Increased Antioxidant Capacity
probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Small
Streptococcus thermophilus PXN 66→Reduced Inflammation
Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients.
Effect
Beneficial
Effect size
Moderate